Turning up Francisella pathogenesis
نویسندگان
چکیده
The unexplained collapse of honeybee (Apis mellifera) colonies across the world continues to fascinate both the scientific and mainstream media alike. This is mainly due to the worldwide importance of honeybees in ecological and commercial sectors. We recently reported how the ectoparasitic mite, Varroa destructor, altered the viral landscape in the Hawaiian archipelago by decreasing the viral genetic diversity while increasing the prevalence of a particular virus species, deformed wing virus (DWV). Here we explain why DWV Virulence News & Views
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Exploring the genetic basis of intracellular pathogenesis in Francisella tularensis
Approved: _______________________________ Thesis Supervisor _______________________________ Title and Department _______________________________ Date 1 EXPLORING THE GENETIC BASIS OF INTRACELLULAR PATHOGENESIS IN FRANCISELLA TULARENSIS by Stephen Robert Lindemann A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Microbiology in the Graduate Col...
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متن کاملAcid phosphatases do not contribute to the pathogenesis of type A Francisella tularensis.
The intracellular pathogen Francisella tularensis is the causative agent of tularemia, a zoonosis that can affect humans with potentially lethal consequences. Essential to Francisella virulence is its ability to survive and proliferate within phagocytes through phagosomal escape and cytosolic replication. Francisella spp. encode a variety of acid phosphatases, whose roles in phagosomal escape a...
متن کاملThe Francisella Intracellular Life Cycle: Toward Molecular Mechanisms of Intracellular Survival and Proliferation
The tularemia-causing bacterium Francisella tularensis is a facultative intracellular organism with a complex intracellular lifecycle that ensures its survival and proliferation in a variety of mammalian cell types, including professional phagocytes. Because this cycle is essential to Francisella pathogenesis and virulence, much research has focused on deciphering the mechanisms of its intracel...
متن کاملThe orange spotted cockroach (Blaptica dubia, Serville 1839) is a permissive experimental host for Francisella tularensis.
Francisella tularensis is a zoonotic bacterial pathogen that causes severe disease in a wide range of host animals, including humans. Well-developed murine models of F. tularensis pathogenesis are available, but they do not meet the needs of all investigators. However, researchers are increasingly turning to insect host systems as a cost-effective alternative that allows greater increased exper...
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